biological tools biology bioinformatics

BBSRC's new Strategic Plan focuses on bioinformatics, systems biology NEW YORK (GenomeWeb News) – Biotechnology in the United Kingdom and science Biological Research Council said it will spend the next five years to promote basic research and development of bioinformatics and systems biology, among the initiatives envisaged in the three-pin revised life sciences strategy unveiled today.
Biology Student Workbench: Inquiry-based Bioinformatics

Protein Networks and Pathway Analysis (Methods in Molecular Biology) $84.81 From the beginning of the OMICs biology era, science has been pursuing the reduction of the complex “genome-wide” assays in order to understand the essential biology that lies beneath it. In Protein Networks and Pathway Analysis, expert practitioners present a compilation of methods of functional data analysis, often referred to as “systems biology,” and its applications in drug discovery, medicin…

Metabolomics: A Powerful Tool in Systems Biology (Topics in Current Genetics) $77.10 The metabolome comprises the complete set of metabolites, the non-genetically encoded substrates, intermediates, and products of metabolic pathways, associated with a cell. Given the increasing demand to quantitatively identify the metabolome and understand how trafficking of metabolites through the metabolic network impact cellular behavior, metabolomics has emerged as an important complementary …

Bioinformatics $71.2 Bioinformatics is a discipline originated by the need of introducing order into massive datasets produced by new technologies of molecular biology: large-scale DNA sequencing, measurements of RNA concentrations in multiple gene expression arrays and new profiling techniques in proteomics. The volume under preparation presents mathematical models in bioinformatics along with descriptions of inspiring biological problems and computer science tools necessary to cope with data. The material covered includes widely used applications in genomics and proteomics and later-generation techniques, which attempts at linking genetic information with structure and function of molecules, metabolic processes and whole cells.

Developing Bioinformatics Computer Skills $27.38 Bioinformatics–the application of computational and analytical methods to biological problems–is a rapidly evolving scientific discipline. Genome sequencing projects are producing vast amounts of biological data for many different organisms, and, increasingly, storing these data in public databases. Such biological databases are growing exponentially, along with the biological literature. It’s impossible for even the most zealous researcher to stay on top of necessary information in the field without the aid of computer-based tools. Bioinformatics is all about building these tools. Developing Bioinformatics Computer Skills is for scientists and students who are learning computational approaches to biology for the first time, as well as for experienced biology researchers who are just starting to use computers to handle their data. The book covers the Unix file system, building tools and databases for bioinformatics, computational approaches to biological problems, an introduction to Perl for bioinformatics, data mining, and data visualization. Written in a clear, engaging style, Developing Bioinformatics Computer Skills will help biologists develop a structured approach to biological data as well as the tools they’ll need to analyze the data. From the Publisher: Developing Bioinformatics Computer Skills will help biologists, researchers, and students develop a structured approach to biological data and the computer tools they’ll need to analyze it. The book covers the Unix file system, building tools and databases for bioinformatics, computational approaches to biological problems, an introduction to Perl for bioinformatics, data mining, data visualization, and tips for tailoring data analysis software to individual research needs.

Bioinformatics for Dummies $18.25 Search databases and analyze sequences like a pro Get the most out of your PC and the Web with the right tools Explore the human genome and analyze DNA — without leaving your desktop! All it takes is the basics of molecular biology and the wealth of information in this friendly guide. You’ll discover the online tools and useful tips you need to ask the right questions, analyze sequences, and compare results. It’s a plain-English introduction to the field! Discover how to Do biological research online Use gene-centric databases Visualize proteins in 3-D Interpret and analyze sequences Produce and publish results

Systems Biology and Bioinformatics $68.43 Emphasizing computational methods, Systems Biology and Bioinformatics provides an introduction to system biology and its impact on biology and medicine. The book reviews the basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. The methods presented in the text include techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. The book also explains how to use system-oriented models to predict the behavior of biological systems for important applications such as rational drug design.

Systems Bioinformatics: An Engineering Case-Based Approach $84.26 This trailblazing guide gives biological and biomedical research engineers a quantitative systems approach to bioinformatics research using computational tools drawn from technical disciplines. A major milestone in systems biology, this groundbreaking work points engineers to new frontiers in the convergence of engineering and biological research.

A Cell Biologist’s Guide to Modeling and Bioinformatics $91.06 A Cell Biologist’s Guide to Modeling and Bioinformatics introduces an array of informatics tools that are available for analyzing biological data and modeling cellular processes. This book combines expert discussion with examples that can be reproduced by the reader, who will quickly learn to fully leverage public databases and create her or his own computational models. Assuming only a working knowledge of algebra and cellular biology, the author provides all the other tools that the reader will need to understand the necessary statistical and mathematical methods.

Bioinformatics for Systems Biology [With CDROM] $118.83 Bioinformatics for Systems Biology [With CDROM]

Bioinformatics and Computational Biology $81.84 Bioinformatics and Computational Biology

Bioinformatics Algorithms $122.36 This book introduces algorithmic techniques in bioinformatics, emphasizing their application to solving novel problems in post-genomic molecular biology. Beginning with a thought-provoking discussion on the role of algorithms in twenty-first-century bioinformatics education, the book covers: general algorithmic techniques, algorithms and tools for genome and sequence analysis, microarray design and analysis, algorithmic issues arising in the analysis of genetic variation across human population, and algorithmic approaches in structural and systems biology.

Bioinformatics and the Cell $139 The many books that have been written on bioinformatics tend to fall on two extremes: books that feature computational details with a great deal of mathematics, for computational scientists and mathematicians, or books that treat bioinformatics mostly as a giant black box, for biologists. Previous books written on bioinformatics often have limited contribution to creating interdisciplinary scientists needed in modern biological and biomedical sciences. This book aims to render both mathematical equations and biology to numbers, to help truly interdisciplinary scientists. Although the book covers bioinformatics methods at a level more advanced than most other bioinformatics books, the extensive numerical illustration of these methods should make it accessible to most senior undergraduate students and graduate students majoring in science and software engineering. Nearly all algorithms in the book are implemented in a free and user-friendly computer program (DAMBE).

Essential Bioinformatics $66.49 Essential Bioinformatics is a concise yet comprehensive textbook of bioinformatics, which provides a broad introduction to the entire field. Written specifically for a life science audience, the basics of bioinformatics are explained, followed by discussions of the state-of-the-art computational tools available to solve biological research problems. All key areas of bioinformatics are covered including biological databases, sequence alignment, genes and promoter prediction, molecular phylogenetics, structural bioinformatics, genomics and proteomics. The book emphasizes how computational methods work and compares the strengths and weaknesses of different methods. This balanced yet easily accessible text will be invaluable to students who do not have sophisticated computational backgrounds. Technical details of computational algorithms are explained with a minimum use of mathematical formulae; graphical illustrations are used in their place to aid understanding. The effective synthesis of existing literature as well as in-depth and up-to-date coverage of all key topics in bioinformatics make this an ideal textbook for all bioinformatics courses taken by life science students and for researchers wishing to develop their knowledge of bioinformatics to facilitate their own research.

Applied Bioinformatics: An Introduction $34.74 Confused by cryptic computer programs, algorithms and formulae? In this book, anyone who can operate a PC, standard software and the Internet will learn to understand the biological basis of bioinformatics of the existence as well as the source and availability of bioinformatics software how to apply these tools and interpret results with confidence. This is aided by introductory chapters to important aspects of bioinformatics, detailed bioinformatics exercises, including solutions and a glossary of definitions and terminology relating to bioinformatics. Quickly learn to manage bioinformatics!

Exploring Bioinformatics $88 Exploring Bioinformatics: A Project-Based Approach is intended for an introductory course in bioinformatics at the undergraduate level. Through hands-on projects, students are introduced to current biological problems and then explore and develop bioinformatic solutions to these issues. Each chapter presents a key problem, provides basic biological concepts, introduces computational techniques to address the problem, and guides students through the use of existing web-based tools and existing software solutions. This progression prepares students to tackle the On-Your-Own Project, where they develop their own software solutions. Topics such as antibiotic resistance, genetic disease, and genome sequencing provide context and relevance to capture student interest.

Fuzzy Systems in Bioinformatics and Computational Biology $145.63 Fuzzy Systems in Bioinformatics and Computational Biology

Grid Computing for Bioinformatics and Computational Biology $119.68 Serving as a single up-to-date reference source, Grid Computing for Bioinformatics and Computational Biology provides details on modern and ongoing research on Grid applications. The book specifically discusses bio-ontology and data mining; data visualization; DNA assembly, clustering, and mapping; molecular evolution and phylogeny; gene expression and micro-arrays; gene identification and annotation; molecular modeling and simulation; molecular sequence analysis; protein structure prediction; sequence assembly; sequence search and alignment; bio data intensive applications; Grid infrastructures; middleware; and tools for bio data.

Algorithms in Bioinformatics $79.95 This classroom-tested text provides an in-depth introduction to the algorithmic techniques applied in bioinformatics. For each topic, the author clearly details the biological motivation, precisely defines the corresponding computational problems, and includes detailed examples to illustrate each algorithm. The text covers basic molecular biology concepts, sequence similarity, the suffix tree, sequence databases, sequence and genome alignment, the phylogenetic tree, genome rearrangement, motif finding, the secondary structure of RNA, peptide sequencing, and population genetics. Supplementary material is provided on the author’’s website and a solutions manual is available for qualifying instructors.

Advances in Computers: Computational Biology and Bioinformatics $148.94 The field of bioinformatics and computational biology arose due to the need to apply techniques from computer science, statistics, informatics, and applied mathematics to solve biological problems. Scientists have been trying to study biology at a molecular level using techniques derived from biochemistry, biophysics, and genetics. Progress has greatly accelerated with the discovery of fast and inexpensive automated DNA sequencing techniques. As the genomes of more and more organisms are sequenced and assembled, scientists are discovering many useful facts by tracing the evolution of organisms by measuring changes in their DNA, rather than through physical characteristics alone. This has led to rapid growth in the related fields of phylogenetics, the study of evolutionary relatedness among various groups of organisms, and comparative genomics, the study of the correspondence between genes and other genomic features in different organisms. Comparing the genomes of organisms has allowed researchers to better understand the features and functions of DNA in individual organisms, as well as provide insights into how organisms evolve over time. The first four chapters of this book focus on algorithms for comparing the genomes of different organisms. Possible concrete applications include identifying the basis for genetic diseases and tracking the development and spread of different forms of Avian flu. As researchers begin to better understand the function of DNA, attention has begun shifting towards the actual proteins produced by DNA. The final two chapters explore proteomic techniques for analyzing proteins directly to identify their presence and understand their physical structure.- Written by active PhD researchers in computational biology and bioinformatics

Fundamental Concepts of Bioinformatics $113.4 Fundamental Concepts of Bioinformatics is the first book co-authored by a biologist and computer scientist that is specifically designed to make bioinformatics accessible and provide readers for more advanced work. Readers learn what programs are available for analyzing data, how to understand the basic algorithms that underlie these programs, what bioinformatic research is like, and other basic concepts. Information flows easily from one topic to the next, with enough detail to support the major concepts without overwhelming readers. Problems at the end of each chapter use real data to help readers apply what they have learned so they know how to critically evaluate results from both a statistical and biological point of view. Focus on fundamentally important algorithms at the core of bioinformatics. For anyone interested in bioinformatics (in biology or computer science), computational biology, molecular biology, or genomics.

Bioinformatics and Molecular Evolution $95.7 In the current era of complete genome sequencing, Bioinformatics and Molecular Evolution provides an up-to-date and comprehensive introduction to bioinformatics in the context of evolutionary biology. This accessible text: bull; bull; provides a thorough examination of sequence analysis, biological databases, pattern recognition, and applications to genomics, microarrays, and proteomics bull; bull; emphasizes the theoretical and statistical methods used in bioinformatics programs in a way that is accessible to biological science students bull; bull; places bioinformatics in the context of evolutionary biology, including population genetics, molecular evolution, molecular phylogenetics, and their applications bull; bull; features end-of-chapter problems and self-tests to help students synthesize the materials and apply their understanding bull; bull; is accompanied by a dedicated website – www.blackwellpublishing.com/higgs – containing downloadable sequences, links to web resources, answers to self-test questions, and all artwork in downloadable format (artwork also available to instructors on CD-ROM). This important textbook will equip readers with a thorough understanding of the quantitative methods used in the analysis of molecular evolution, and will be essential reading for advanced undergraduates, graduates, and researchers in molecular biology, genetics, genomics, computational biology, and bioinformatics courses.

Statistics Applied to Bioinformatics $130 A text based on his Masters level course on statistics applied to bioinformatics aimed at graduate students from statistics, bioinformatics and biology. Filling a gap in the current literature, the text includes a rigorous and extensive background in biostatistics, along with detailed explanation of the key biological questions before focusing on the statistical analysis. Including exercises, numerous illustrations, extensive end of chapter summaries and examples of programming in R (a freely available statistical package), this is an ideal study text.

An Introduction to Bioinformatics Algorithms $50.66 This introductory text offers a clear exposition of the algorithmic principles driving advances in bioinformatics. Accessible to students in both biology and computer science, it strikes a unique balance between rigorous mathematics and practical techniques, emphasizing the ideas underlying algorithms rather than offering a collection of apparently unrelated problems.The book introduces biological and algorithmic ideas together, linking issues in computer science to biology and thus capturing the interest of students in both subjects. It demonstrates that relatively few design techniques can be used to solve a large number of practical problems in biology, and presents this material intuitively. An Introduction to Bioinformatics Algorithms is one of the first books on bioinformatics that can be used by students at an undergraduate level. It includes a dual table of contents, organized by algorithmic idea and biological idea; discussions of biologically relevant problems, including a detailed problem formulation and one or more solutions for each; and brief biographical sketches of leading figures in the field. These interesting vignettes offer students a glimpse of the inspirations and motivations for real work in bioinformatics, making the concepts presented in the text more concrete and the techniques more approachable.PowerPoint presentations, practical bioinformatics problems, sample code, diagrams, demonstrations, and other materials can be found at the Author’s website.

Knowledge Discovery in Bioinformatics $98.61 The purpose of this edited book is to bring together the ideas and findings of data mining researchers and bioinformaticians by discussing cutting-edge research topics such as, gene expressions, protein/RNA structure prediction, phylogenetics, sequence and structural motifs, genomics and proteomics, gene findings, drug design, RNAi and microRNA analysis, text mining in bioinformatics, modelling of biochemical pathways, biomedical ontologies, system biology and pathways, and biological database management.

Bioinformatics Methods and Protocols $109 Hands-on users and experts survey the key biological software packages, offering useful tips and an overview of current developments. Among the sequence analysis systems reviewed are GCG, Omiga, MacVector, DNASTAR, PepToola [, GeneToola [, and the Staden Package. Molecular biology software includes Genotator and sequence-similarity searching using FASTA, CLUSTAL multiple sequence alignment, and phylogenetic analysis. Web-based resources are examined for primary sequence databases, primary sequence analysis methods, and clinical databases useful in molecular medicine. Numerous illustrative examples to teach the reader how to solve problems are included. Bioinformatics: Methods and Protocols constitutes a gold-standard reference for today''s scientists who wish to develop and hone their bioinformatics skills towards the discovery of new biological relationships.

Java for Bioinformatics and Biomedical Applications $86.67 The science and practice of medicine has undergone a fundamental change as a result of large-scale genome projects that led to the sequencing of a number of important microbial, plant and animal genomes in the last 5 years. This book aims to combine industry standard software engineering and design principles, genomics and bioinformatics and cancer research. It focuses on creating and integrating practical, useful tools for the scientific community in the context of real-life, real-value biomedical problems that researchers face on a routine basis, rather than being just a didactic exercise in learning a programming platform. The book leverages technologies for molecular biology, genomics and bioinformatics and cancer research developed by the NIH, NCI-Center for Bioinformatics (NCICB), the National Center for Biotechnology Information (NCBI, a division of the National Library of Medicine (NLM) at the NIH) and Stanford University.

Bioinformatics In The Post-Genomic Era $38.03 Bioinformatics in the Post-Genomic Era Genome, Transcriptome, Proteome, and Information-Based Medicine Augen' s book provides a thorough review of bioinformatics that presages the coming era of information-based medicine. --John Reynders, VP of Informatics, Celera Genomics Augen is to be congratulated on producing an indispensable book. He not only lays out and explains the essential tools in bioinformatics, but he also validates the critical role that computational biology will play in the future of medical research. This is a fabulous achievement--there is something here for novice and expert alike. --Kevin Davies, Editor-in-Chief, Bio-IT World Jeff has created an erudite, yet amazingly accessible overview of the intersection between biology, biomedicine, and high-performance computing. --Andrea Califano, Director, Genome Center Bioinformatics, Columbia University This book is essential for anyone wishing to understand the information technology transformation of the life sciences. --W.R. Pulleyblank, Director, Deep Computing Institute, IBM Research Because of its unusually broad scope, Jeff Augen' s new book has the capacity to deliver value to a wide variety of audiences. As a longtime investor in biotechnology and healthcare, I find the discussions surrounding the future of medicine and information technology particularly interesting and useful. --G. Steven Burrill, Chief Executive Officer, Burrill and Company Augen takes you on a complete guided tour of computational biology, combining historical perspectives with discussions of the leading-edge technologies being employed today. This book would be useful for anyone in thefield. It provides an entire overview to scientists new to computational biology, while giving experts detailed information about new developments in the field. --Salvatore Salamone, Senior IT Editor, Bio-IT World and Health-IT World There are books about bioinformatics with a focus on information technology and books on molecular biology with a focus on bioscience, but I am not aware of any book that provides a summary of fundamentals of both bioscience and information science with a technical bridge between the two disciplines. This book is unique in covering theoretical and practical aspects of bioinformatics. Everyone from biologists and geneticists to computer scientists and engineers will benefit from Augen' s book. --O.K. Baek, Chief Architect, Biomedical Informatics and Information-Based Medicine, IBMToday, advances in high-performance computing, data management, and the Internet are transforming many aspects of biomedical research and have produced a new generation of tools for studying gene and protein sequences, macromolecular structures, and metabolic systems. These tools have greatly accelerated the drug discovery and testing process and promise to change the way diseases are predicted and treated in the future. Bioinformatics in th

Statistical Methods In Bioinformatics $104 Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated to address extremely complex biological questions. Correspondingly, advances in the statistical methods necessary to analyze such data are following closely behind the advances in data generation methods. The statistical methods required by bioinformatics present many new and difficult problems for the research community. This book provides an introduction to some of these new methods. The main biological topics treated include sequence analysis, BLAST, microarray analysis, gene finding, and the analysis of evolutionary processes. The main statistical techniques covered include hypothesis testing and estimation, Poisson processes, Markov models and Hidden Markov models, and multiple testing methods. The second edition features new chapters on microarray analysis and on statistical inference, including a discussion of ANOVA, and discussions of the statistical theory of motifs and methods based on the hypergeometric distribution. Much material has been clarified and reorganized. The book is written so as to appeal to biologists and computer scientists who wish to know more about the statistical methods of the field, as well as to trained statisticians who wish to become involved with bioinformatics. The earlier chapters introduce the concepts of probability and statistics at an elementary level, but with an emphasis on material relevant to later chapters and often not covered in standard introductory texts. Later chapters should be immediately accessible to the trained statistician. Sufficient mathematical background consists ofintroductory courses in calculus and linear algebra. The basic biological concepts that are used are explained, or can be understood from the context, and standard mathematical concepts are summarized in an Appendix. Problems are provided at the end of each chapter allowing the reader to develop aspects of the theory outlined in the main text. Warren J. Ewens holds the Christopher H. Brown Distinguished Professorship at the University of Pennsylvania. He is the author of two books, Population Genetics and Mathematical Population Genetics. He is a senior editor of Annals of Human Genetics and has served on the editorial boards of Theoretical Population Biology, GENETICS, Proceedings of the Royal Society B and SIAM Journal in Mathematical Biology. He is a fellow of the Royal Society and the Australian Academy of Science. Gregory R. Grant is a senior bioinformatics researcher in the University of Pennsylvania Computational Biology and Informatics Laboratory. He obtained his Ph.D. in number theory from the University of Maryland in 1995 and his Masters in Computer Science from the University of Pennsylvania in 1999. Comments on the First Edition. This book would be an ideal text for a postgraduate courseb&[and] is equally well suited to individual studyb&. I would recommend the book h

Biology $82.95 Biology: The Dynamic Science is the first general biology text with an experimental approach that connects historical research, recent advances achieved with molecular tools, and a glimpse of the future through the eyes of prominent researchers working on key unanswered questions of the day. This comprehensive framework doesn’t come at the expense of essential concepts. Rather, it provides a meaningful, realistic context for learning all of the core material that students must master in their first course. Written from the ground up with minimal jargon and crisp, straight forward explanations of the current state of biological knowledge, the text supports students as they learn the scientific process-and how to think as scientists do.

Introduction to Bioinformatics: A Theoretical and Practical Approach $144.99 A comprehensible introduction to the key biological, mathematical, statistical, and computer concepts and tools behind bioinformatics. For physical scientists, the book provides a sound biological framework for understanding the questions a life scientist would ask in the context of currently available computational tools. For life scientists, a complete discussion of the UNIX operating system offers biologists graphical-user-interface comfort in a command-line environment, plus an understanding of the installation and management of UNIX-based software tools. In the applications sections the book provides a common meeting ground for life and physical scientists. Here they will find examples of the management and analysis of DNA sequencing projects, the modeling of DNA as a statistical series of patterns, various methods of pattern discovery, protein visualization, and the use of multiple sequence alignment to infer both functional and structural biological relationships. An accompanying CD contains several full and limited trial-versions of the programs discussed in the text, as well as a complete set of illustrations from each chapter suitable for lectures and presentations.

Bioinformatics and Systems Biology $113.58 Collaborative research in bioinformatics and systems biology is a key element of modern biology and health research. This book highlights and provides access to many of the methods, environments, results and resources involved, including integral laboratory data generation and experimentation and clinical activities. Collaborative projects embody a research paradigm that connects many of the top scientists, institutions, their resources and research worldwide, resulting in first-class contributions to bioinformatics and systems biology. Central themes include describing processes and results in collaborative research projects using computational biology and providing a guide for researchers to access them. The book is also a practical guide on how science is managed. It shows how collaborative researchers are putting results together in a way accessible to the entire biomedical community.